Abstract: #974 HCV Clearance Is Associated with an Increase in Cardiovascular Risk – Varun K.Takyar, et al.
People living with HCV tend to have low lipid profiles (cholesterol and triglycerides). After HCV is eradicated, an increase in lipids is common. Researchers wondered if these higher lipids increases risk of cardiovascular disease. Evaluating 60 subjects undergoing HCV treatment, this small study compared the pre-treatment cardiovascular risk to the 24-week post-treatment risk.
Conclusion: When people cleared HCV, their lipoproteins increased, which in turn raises cardiovascular risk. The researchers recommended that, “Patients should be evaluated for cardiovascular risk and need for lipid lowering therapy after HCV clearance.”
Editorial Comments: I have three problems with this study. First, the study used an extremely small sample. Second, the length of the study; I wonder what these data would be in one, five, and ten years. Third, (and most importantly), this study needs to have a control arm. Other studies show that people with HCV have an increased risk of cardiovascular disease. But, if you read this study, it appears that people who are cured are at increased risk. With no comparison to people without HCV, we don’t really know what the risk is, especially with data that are small and short-term.
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