AASLD 2016: The Liver Conference – Alan Franciscus
Source: Abstract # 964:
Viral response to hepatitis C direct-acting antivirals significantly improves diabetes control—S B LeCler at. al
Insulin resistance is believed to be caused by the hepatitis C virus. But diabetes is not believed to cause diabetes. But does successful treatment help to reduce some measurements of the disease? This is what the study examined. The study looked at the effect of direct-acting antiviral (DAA) treatment on diabetic medications. The authors identified studies from February 1, 2014 through October 1, 2015 that included 131 patients who received DAA treatment and who also received diabetes medications.
The majority of the patients were male (98%), the average age was 63, and the majority of patients were black (59%) and had advanced fibrosis (53%).
Conclusions: Of the 122 patients who achieved a cure 27% (33 of 122 patients) lowered their diabetic medications from baseline measurement to 3 months post-treatment compared to 11% (1 of 9 patients) of the HCV DAA replaspers who did not. Of the available data on A1C—A1C is an average measurement of glucose over a three-month period—there was a significant decrease of 0.63% percentage points.
Editorial Comments: This is a small but interesting study. It needs to be replicated in much larger studies to confirm the results. Anecdotally, I hear from many people that being cured has helped to improve their blood sugar levels. Patients would certainly benefit from monitoring their blood sugar levels after being cured and working with their medical providers to find out if their diabetes medications need to be adjusted.
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