AASLD 2016 Conference Coverage – Merck
C-Crest: The trial was a phase 2 study of a 3-drug co-formulation of MK-3682 (polymerase inhibitor), grazoprevir (protease inhibitor) plus ruzasvir (NS5A inhibitor) with and without ribavirin to treat HCV genotypes 1, 2 and 3. The treatment period was 8, 12 or 16 weeks. In the people who were previously treated with pegylated interferon plus ribavirin the SVR12/cure rates were 95% to 100% in genotype 1a, 1b and 3. In people with genotype 2 the cure rate was 87% in the 8-week group and a 100% rate in the 12 week group and 96% to 98% in the 16 week groups. There was very little difference in cure rates between the groups who had cirrhosis, and who did/did not receive ribavirin.
C-Surge: An on-going phase 2 study to treat people with genotype 1 who had failed a previous course of a direct-acting antiviral therapy (Harvoni or Zepatier) using MK-3682, grazoprevir and ruzasvir with and without ribavirin. In the group that received ribavirin the treatment duration was 16 weeks; in the group that did not receive ribavirin the treatment duration was 24 weeks. The SVR 8 results were 98% in the 16 week group that received ribavirin and 100% in the 24 week group that did not receive ribavirin.
Alan Franciscus is the Executive Director of the Hepatitis C Support Project and the Editor-in-Chief of the HCV Advocate Website
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