Abstract # 210: Identification of Novel HCV Genotype and Subtypes in Patients Treated with Sofosbuvir Based Regimens—C. Hedskog, et al.
In the current study, the authors analyzed hepatitis C (HCV) genotype and subtypes from more than 14,000 patients treated with sofosbuvir-based regimes.
Fifty-five patients had unresolved subtypes. The study goal was to identify the unresolved HCV genotype/subtype.
Currently, there are 7 HCV genotypes (1-7) and 86 HCV subtypes. There is a genetic variance of ≥ to a 30% between HCV genotypes and approximately a 15% genetic variance between HCV subtypes.
Conclusion: Of the 55 unresolved HCV subtypes: 13 were known HCV subtypes; 19 were newly discovered HCV subtypes—mostly in HCV genotypes 2 and 4. Two of the unresolved types were HCV genotype 8—a newly identified HCV genotype. There were still some patients that they were not able to identify their sequences.
Editorial Comments: This study reminds us how much we still need to learn about HCV. New subtypes, new genotypes and more medical conditions linked to HCV underscore the need for more research dollars to understand the many facets of HCV.
Note: Two additional HCV genotype 8 patients have been identified in Canada.
Source: NATAP from The Liver Meeting Presentation
To read the entire newsletter, click here
Alan Franciscus is the Executive Director of the Hepatitis C Support Project and the Editor-in-Chief of the HCV Advocate Website.Share This Page