Source Abstract # THU-204 Understanding factors associated with hepatitis C spontaneous viral clearance: a meta-analysis –D. N. Aisyah et al.
Study Aims and Results
The study analyzed the rate of spontaneous or natural clearance of hepatitis C after becoming acutely infected. The authors reviewed various studies (meta-analysis) from several databases (Ovid Embase, Ovide Medline, Pubmed) from 1/1/1994 – 6/30/2015 to understand the time of acute infection to spontaneous clearance and the factors associated with spontaneous clearance. Forty-four studies of 20,409 people were included in the review.
Approximately 1/5 of those who cleared hepatitis C did so within 3 months, 1/3 did so in 6 months and over 1/3 did so in 12 months. If people did not clear the virus by 12 months they were unlikely to clear the virus.
The groups that were less likely to spontaneously clear the virus early in the acute phase included males, those who did not have a hepatitis B co-infection, who lacked hepatitis C symptoms, black race, non-genotype 1, older age, those with alcohol or drug use and people with HIV.
There are two important outcomes from this study:
1. It clearly shows that 12 months establishes the time period needed to ascertain the time to spontaneously clear the hepatitis C virus from the body in most people acutely infected with hepatitis C. But it is important to take note of the exceptions listed above. (see the abstract below to treat acute HCV in people with HIV for an example of why it’s important to treat sooner than the above date range.)
- It gives a better understanding of who and when to treat with direct-acting antiviral therapy for those who have been recently infected with the hepatitis C virus.
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