Lupus and Hepatitis C – Alan Franciscus
This was one of the largest studies to date on the association between system lupus erythematosus—lupus—and hepatitis C to date. Lupus is an autoimmune disease. It was conduct by Clalit Health Services in Israel and compared people with lupus (5,018) against people without lupus (25,090). They then looked at the rate of hepatitis C in both groups. The incidence of hepatitis C was 1.06% in the group with lupus and 0.39% in the group without lupus. The study shows that there is an association but it does not prove that hepatitis C causes lupus—an important distinction.
This is not the first study to show an association between lupus and hepatitis C but it is the largest and adds important information to the body of knowledge.
To learn more about lupus and other extrahepatic manifestations of hepatitis C visit our Extrahepatic Manifestation Glossary. Note: we have recently changed this glossary and our medical glossary format so you can search it or scroll it alphabetically.
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Article: Chronic hepatitis C viral infection among SLE patients: the significance of coexistence—N Mahroum
Source: Immunol Res. 2017 Jan 23. doi: 10.1007/s12026-016-8886-7. [Epub ahead of print]
The association between viral infection and autoimmune diseases is an established phenomenon in medicine. Hepatitis C viral infection is known to have such an association; however, its association with systemic lupus erythematosus has not been studied in a real life study driven from a large national database.
The objective of this study was to investigate the association between SLE and chronic hepatitis C viral infection. Patients with SLE were compared with age-and sex-matched controls regarding the proportion of chronic HCV infection. Chi-square and t tests were used for univariate analysis, and a logistic regression model was used for multivariate analysis. The study was performed utilizing the medical database of Clalit Health Services in Israel.
There was a significant higher proportion of hepatitis C viral infection in SLE patients as compared to controls (1.06 and 0.39%, respectively; p < 0.001). A significant association was also observed among patients of higher socioeconomic status. In a multivariate logistic regression analysis, SLE was significantly associated with hepatitis C viral infection (OR = 2.07, 95% CI = 1.46-2.90).
To conclude, Patients with SLE have a greater proportion of chronic HCV infection than matched controls.Share This Page