Abstract: THU-099 Lowering the upper limit of serum alanine aminotransferase levels may detect significant liver disease in the elderly – H. Schmilovitz-Weiss, et al.
Study Aims and Results: A common first blood test used to assess liver injury is measuring serum alanine aminotransferase (ALT), which is a liver enzyme. Some experts believe that the current normal ranges for ALT may be too high. If so, one may have liver injury despite the test result being technically normal.
In this study, researchers compared normal ALT results between previous normal ranges and newly suggested ranges of 49,634 individuals aged ≥ 65 years. The standard normal ranges were 42–45 IU/l for men and 26–34 IU/l for women. The newly suggested normal ranges were 15–42 IU/L for men and 10–26 IU/L for women.
Using the standard ranges, researchers found that people whose ALTs were on the high side of the normal range had higher rates of chronic liver disease. They identified 2022 people with chronic liver disease although they had normal ALT levels; 366 had cirrhosis.
Conclusions: These researchers concluded that lowering the current normal ranges of serum ALT might help to identify significant liver disease in the elderly.
Editorial Comments: If your liver enzymes consistently fall in the upper range of normal, talk to your healthcare provider. Ask if you need to be referred to a liver specialist.Share This Page