Source: Abstract # THU 271: Improvement of glycemic state among responders to sofosbuvir-based DAAs—S. A Alem et. al.
Study Aims and Results: Egypt has the highest percentage of hepatitis C worldwide as HCV genotype 4 is the most common one in Egypt. The aim of the study was to understand the effect of sofosbuvir-based therapy on blood sugar levels.
Sixty patients—mostly male (70%); mean age 55yo; 48% cirrhotic; treatment naïve (70%) were treated with a variety of sofosbuvir-based therapies including simeprevir, ledipasvir or daclatasvir with and without ribavirin. The treatment period was 12 weeks. Thirty-six patients were on oral diabetic medications; 7 patients were on oral and insulin diabetic medications and one patient was on no diabetic medication. The fasting blood sugar levels (FBS) and hemoglobin A1C (HbA1c) were assessed at week 0 (baseline) and at 12-week post follow-up (SVR12-cure).
All of the patients in the study were cured of hepatitis C. There was a significant decline in the FBS and HbA1c between baseline and at the time of cure regardless of which drug was combined with sofosbuvir. The decline in FBS and HbA1c was more significant in the cirrhotic patients.
Conclusions: Treatment of hepatitis C in people with diabetes resulted in a significant decline in fasting FBS and HbA1c levels.
Editorial Comments: The link between diabetes and hepatitis C is a controversial issue. This study shows that there is an improvement in the levels of blood sugar numbers. Before drawing final conclusion I will need to read the journal article to support this study. As someone who is living with diabetes, I hope that this and other studies support the conclusion that being cured of hepatitis C improves the outlook of people with hepatitis C and diabetes.
*Fasting blood sugar levels (FBS) is a blood test —usually done in the morning before someone has eaten. The normal levels of fasting blood sugar levels are 70 to 100 mg/dl.
*Hemoglobin A1C (HbA1c) – sugar (glucose) substances becomes ‘stuck’ to hemoglobin—molecules in the blood. The test can measure how much of the sugar has become ‘stuck’ to hemoglobin over the previous three months. It is a test that is used to understand how well type 1 and type 2 diabetes is being controlled.Share This Page