STUDY ABSTRACT: FRI-374 The impact of sustained virologic response on severe fatigue in patients with chronic hepatitis C: the role of HCV viremia and co-morbidities – Z. Younossi, et. al.
Study Aims and Results: To assess the effect of being cured of HCV on fatigue. Patients enrolled in phase 2 and phase 3 sofosbuvir-based clinical trials were given a FACIT-F instrument fatigue scale test before beginning treatment and at post-treatment week 12. There were 6,113 patients (mean age 53 yo, 56% male, 40% employed, 35% cirrhotic, 28% reported a history of anxiety, 43% had a history of depression, 15% had type 2 diabetes, and 7% were coinfected with HIV). After taking the FACIT-F fatigue scale before treatment, 1,427 of the participants tested for the most severe fatigue.
After cure: In the people who had severe fatigue before treatment, 42% continued to have severe fatigue, 45% of patients improved to moderate fatigue, and 13% improved to minimal or no fatigue. The patients who were more likely to have improved scores were younger, less likely to have cirrhosis and lower rates of depression, anxiety, sleep disorders, diabetes and HIV coinfection.
Conclusion: Being cured of HCV reduced the symptoms of fatigue but managing the other symptoms of the patients is equally important to reducing fatigue post-treatment and cure.
Editorial Comment: Hepatitis C is a disease that affects the entire body, not just the liver. We need to attend to healing the whole body, not just the liver.Share This Page