Source: Abstract # THU-244 Treatment with direct-acting antiviral agents is associated with improvement of renal function in a cohort of hepatitis C virus infected patients with chronic kidney disease—C Masetti et.al.
Study Aims and Results: The hepatitis virus causes kidney disease through a complex process of an interaction with the immune system, the liver and the kidney.
The goal of the study was to understand the improvement in kidney function after being cured of hepatitis C.
The study included 42 HCV patients with kidney disease (38 pts stage III; 2 pts stage IV; 2 pts stage V). Note: Kidney disease is staged from Stage 1 to Stage 5 with Stage 1 mild kidney disease through Stage 5 kidney failure.
The results reported are end-of-treatment results. All patients were HCV RNA (viral load) negative. The cure rates are pending. Seventy-four percent had an improvement in kidney function. The increase in kidney function was more pronounced in people with cirrhosis. Seven patients (17%) had a slight worsening of kidney functioning.
Conclusion: The majority of patients with impaired kidney function who had an undetectable end-of-treatment response had improvements in kidney functions. Some patients (17%) had a slight worsening of kidney functions.
Editorial Comments: This is good news for people with hepatitis C and kidney disease. I want to see more information about the slight worsening of kidney functioning. I also want to understand if the results are different once the cure rates are known and if the kidney function has recovered once significant time has elapsed.
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